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Loredana DE BARTOLO



PhD. Dr.


Email:
l.debartolo
@itm.cnr.it  -  loredana.debartolo@cnr.it

Tel: +39 0984 492036

Address:
Institute on Membrane Technology (CNR-ITM) 
c/o University of Calabria 
Via P. Bucci cubo 17/C 
87030 Rende CS



   

Biographical Note

Loredana De Bartolo has a degree cum laude in Biology and a doctorate in Chemical Technologies and New Materials from the University of Calabria (Italy). She performed an Alexander Von Humboldt Foundation Post doc in Leibniz Institute for Biotechnology and Artificial Organs, Medzinische Hochschule of Hannover (Germany). She is senior research scientist of the Institute on Membrane Technology of the National Research Council of Italy (ITM-CNR) and research leader of the development of membrane systems in tissue engineering and regenerative medicine at the ITM-CNR.
Her research experiences are in the fields of bioartificial membrane systems including membrane bioreactors applied to tissue engineering and regenerative medicine, with special focus on the development of liver, neuronal, bone and skin system. Her main distinction and contribution in the field is her specific knowledge about stem cell-membrane and biomaterial interactions. She is founding member of European and World Federation Regenerative Medicine (2006) and of the World Virtual Institute – Preventive and Regenerative Medicine (2009).
Dr. De Bartolo is coordinator and scientific responsible of several national, bilateral and european projects including Livebiomat project that has been selected by European Commission as one of success stories in the materials field. She is involved as chairperson in various congress sessions and in several international committees and in editorial board of prestigious scientific journals. She is  associate editor of Cells Tissues & Organs and served as guest editor of Current Stem Cell Research & Therapy. She is author/coauthor of over 100 peer-reviewed papers and has made more than 95 presentations to scientific meetings worldwide including invited and keynote lectures.

Research

  • Development of membrane biohybrid systems and bioartificial organs in regenerative medicine
  • Development of membrane biohybrid systems for in vitro study of drugs and disease (hepatocytes, lymphocytes, neurons, stem cells, keratinocytes, epithelial cells)
  • Study of cell/blood-membrane interactions
  • Membrane separation processes for the blood filtration


Responsability for research projects

  1. Scientific responsible for CNR of european project BIOART— Training network for developing innovative (bio)artificial devices for treatment of kidney and liver disease. FP7-PEOPLE-2012-ITN Project No. 316690 (2012-2016)
  2. Scientific responsible for CNR of european project Biomaterials for trachea replacement in age-related cancer humanly engineered airway – BIOtrachea”, FP7 NMP3- SL-2012-280584 (2012-2017).
  3. Scientific responsible for CNR of transnational project MATERA ERANET SCATE BHH-2177 “Scaffolds for tissue engineering” grnated by MIUR decreto 366/Ric.2011-2014 (2011- 2014).
  4. Member of Cost Action NAMABIO MP1005 From nano to macro biomaterials (design, processing, characterization, modeling) and applications to stem cells regenerative orthopedic and dental medicine (NAMABIO) 2011-2015.
  5. Italian scientific responsible of bilateral project “Study of the chitosan-cell membrane interactions for the neuronal regeneration” CNR-CNPq Italy-Brazil between  ITM-CNR and Institute of Physics of São Carlos - IFSC, University of São Paulo (2010-2011) Prot. No. 0030504.
  6. Italian scientific responsible of bilateral project: “Development of biocompatible membranes to be used in bioartificial skin” CNR-PAN Italy-Polonia between ITM-CNR and Institute of Biocybernetic and Biomedical Enginieering Polish Academy of Sciences (2010-2012) No.0016978.
  7. Principal Investigator for the workpackage “Membrane systems in regenerative medicine, tissue engineering” of the research project “Membrane systems in regenerative medicine, tissue engineering and biotechnology” granted by King Abdulaziz City of Science and Technology (KACST), Kingdom of Saudi Arabia KACST-ITM_03 (2010-2013).
  8. Scientific responsible for CNR of european project LIVEBIOMAT NMP3-CT-013653 “Development of new polymeric biomaterials for in vitro and in vivo liver reconstruction” (2005- 2008).
  9. Coordinator and scientific responsible of the FIRB Project (RBNE012B2K): “Sviluppo di un bioreattore a membrana per la coltura di epatociti primari come sistema modello per lo studio in vitro di metaboliti, nuove molecole farmacologiche e mediatori della risposta infiammatoria” granted by MIUR with Decreto Ministeriale 25 june 2002 prot. n. 853-Ric./2002 (2002- 2006).
  10. Member of European Space Agency topical team for the project “Controlled Tissue Development in Bioreactor” BTT-01(2000 –2005)
  11. Scientific responsible for CNR-ITM for the workpackage “WP11.4. Health” del European Network of Excellence on Nanoscale-based membrane technologies (NanoMemPro 500623-2-26-7- 2004) (2004-2008).
  12. Italian scientific responsible of bilateral project CNR-INSERM, Consiglio Nazionale delle Ricerche– Institut National de la Santé et de la Recherche Médicale: Semipermeable membranes as means for cell oxygenation and as immunoselective barriers, between ITM-CNR and UMR CNRS 6600 – Biomecanique et Genie Biomedical, Université de Technologie de Compiègne, Centre de Recherches de Royalliau. (2001-2002 and 2003-2004)

Visiting scientist:

  • Institute of Physics of São Carlos - IFSC, University of São Paulo (Brasil) Marzo 2011e Marzo 2012
  • Institute of Biocybernetic and Biomedical Enginieering Polish Academy of Sciences (Poland) December 2010
  • University of Missouri, Columbia (USA) 2008
  • Biomedical-Biotechnological Center, BBZ, University of Liepzig, Germany - 2006
  • CNRS UMR CNRS 6600 – Biomecanique et Genie Biomedical, Université de Technologie de Compiègne, Centre de Recherches de Royalliau, Compiegne - 2005
  • Leibniz Institute for Biotechnology and Artificial Organs (LEBAO), Medizinische Hochschule Hannover (Germany) - 1997


Highlights

                   
https://www.degruyter.com/view/product/179446     https://www.karger.com/Journal/Issue/276655


                                                                      
https://www.crcpress.com/product/isbn/9781466576391   



EUR 23581 EN – Success stories in the materials field
A decade of EU-funded research
Luxembourg: Office for
Official Publications of the European Communities 2008
DOI 10.2777/96506ISBN 978-92-79-09669-3


             

cnr.it Highlights 2008-2009               cnr.it Highlights 2009-2010



Contribution in the front cover of the Journal Macromolecular Bioscience

Select Publications 

  1. Khakpour, A. Di Renzo, E. Curcio, F. Paolo Di Maio, L. Giorno, L. De Bartolo. Oxygen transport in hollow fiber membrane bioreactors for hepatic 3D cell culture: a parametric study. Journal of Membrane Science 2017; 544:312-322. http://dx.doi.org/10.1016/j.memsci.2017.09.024
  2. M.M. Ahmed, S. Salerno, A. Piscioneri, S. Khakpour, L. Giorno, L. De Bartolo. Human liver microtissue spheroids in hollow fiber membrane bioreactor. Colloids and Surfaces B: Biointerfaces 2017; 160: 272-280. http://dx.doi.org/10.1016/j.colsurfb.2017.09.024
  3. Ahmed, S. Salerno, S. Morelli, L. Giorno, L. De Bartolo. 3D liver membrane system by co-culturing human hepatocytes, sinusoidal endothelial and stellate cells. Biofabrication 2017; 9, 2: 025022. https://doi.org/10.1088/1758-5090/aa70c7.
  4. Morelli, A. Piscioneri, S. Salerno, C.-C. Chen, C.H. Chew, L. Giorno, E. Drioli, L. De Bartolo. Microtube array membrane bioreactor promotes neuronal differentiation and orientation. Biofabrication 2017; 9, 2: 025018. https://doi.org/10.1088/1758-5090/aa6f6f.
  5. De Bartolo, E. Curcio and E. Drioli. Membrane systems for bioartificial organs and regenerative medicine. De Gruyter, 2017. DOI 10.1515/9783110268010-001; ISBN 978-3-11-026798-3; eBook ISBN 978-3-11-026801-0
  6. Salerno, A. Messina, F. Giordano, A. Bader, E. Drioli, L. De Bartolo. Dermal-epidermal membrane systems by using human keratinocytes and mesenchymal stem cells isolated from dermis. Materials Science & Engineering C - Materials for Biological Applications 2017; 71: 943–953. DOI: 10.1016/j.msec.2016.11.008
  7. Salerno, S. Morelli, F. Giordano, A. Gordano, L.De Bartolo. Polymeric membranes modulate human keratinocyte differentiation in specific epidermal layers. Colloids and Surfaces B: Biointerfaces 2016; 146: 352–362. DOI: http://dx.doi.org/10.1016/j.colsurfb.2016.06.026
  8. Morelli, S. Salerno, A. Piscioneri, F. Tasselli, E. Drioli, L. De Bartolo. Neuronal membrane bioreactor as a tool for testing crocin neuroprotective effect in Alzheimer’s disease. Chemical Engineering Journal 2016; 305:69-78. DOI 10.1016/j.cej.2016.01.035
  9. Messina, S. Morelli, G. Forgacs, G. Barbieri, E. Drioli, L. De Bartolo. Self-assemblying of tissue spheroids on polymeric membranes. Journal of Tissue Engineering and Regenerative Medicine 2017; 11: 2090–2103, DOI: 10.1002/term.2105.
  10. Morelli, A. Piscioneri, A. Messina S. Salerno, Mohamed B. Al-Fageeh, E. Drioli, L. De Bartolo. Neuronal growth and differentiation on biodegradable membranes. Journal of Tissue Engineering and Regenerative Medicine 2015; 9: 106–117. DOI: 10.1002/term.1618
  11. Morelli, S. Salerno, J. Holopainen, M. Ritala, L. De Bartolo. Osteogenic and osteoclastogenic differentiation in polylactic acid-nanohydroxyapatite fiber scaffolds. Journal of Biotechnology 2015; 204: 53–62; DOI: 10.1016/j.jbiotec.2015.03.023.
  12. Piscioneri, S. Morelli, M. Mele, M. Canonaco, P. Pantano, E. Bilotta, E. Drioli, L. De Bartolo. Neuroprotective Effect OF Human Mesenchymal Stem Cells in a Compartmentalized Neuronal Membrane System. Acta Biomaterialia 2015; 24: 297–308. http://dx.doi.org/10.1016/j.actbio.2015.06.013.
  13. De Bartolo and A. Bader. Biomaterials for Stem Cell Therapy: State of Art and Vision for the Future. CRC Press: Boca Raton FL, 2013. ISBN 9781466576391.
  14. Curcio, A. Piscioneri, S. Salerno, F. Tasselli, S. Morelli, E. Drioli, L. De Bartolo. Human lymphocytes cultured in 3-D bioreactors: Influence of configuration on metabolite transport and reactions. Biomaterials 2012; 33:8296-8303.
  15. Morelli, A.Piscioneri, S. Salerno, M. Rende, C. Campana, F. Tasselli, A. di Vito, G. Giusi, M. Canonaco, E. Drioli and L. De Bartolo. Flat and tubular membrane systems for the reconstruction of hippocampal neuronal network. J Tissue Eng Regen Med 2012; 6: 299–313.
  16. De Bartolo, A. Leindlein, D. Hofmann, A. Bader, A. de Grey, E. Curcio, E. Drioli. Bio-Hybrid Organs and Tissues for Patient Therapy: a Future Vision for 2030. Chem Eng & Process: Proc Intensif 2012; 51:79– 87.
  17. Salerno, C. Campana, S. Morelli, E. Drioli, L. De Bartolo. Human hepatocytes and endothelial cells in organotypic membrane systems. Biomaterials 2011, 32 (2011) 8848-8859.
  18. Piscioneri, C. Campana, S. Salerno, S. Morelli, A. Bader, F. Giordano, E. Drioli, L. De Bartolo. Biodegradable and synthetic membranes for the expansion and functional differentiation of rat embryonic liver cells. Acta Biomaterialia 2011, 7:171-179
  19. Morelli, S. Salerno, A. Piscioneri, B.J. Papenburg, A. Di Vito, G. Giusi, M. Canonaco, D. Stamatialis, E. Drioli, L. De Bartolo. Influence of micropatterned PLLA membranes on the outgrowth and orientation of hippocampal neuritis. Biomaterials 2010, 31: 7000-7011
  20. Pavlica, A. Piscioneri, F. Peinemann, M. Keller, J. Milosevic, A. Staeudte, A. Heilmann, M. Schulz-Siegmund, S. Laera, P. Favia, L. De Bartolo, A. Bader. Rat embryonic liver cell expansion and differentiation on NH3 plasma-grafted PEEK-WC-PU membranes. Biomaterials 2009; 30: 6514–6521.
  21. Salerno, A. Piscioneri, S. Laera, S. Morelli, P. Favia, A. Bader, E. Drioli, L. De Bartolo. Improved functions of human hepatocytes on NH3 Plasma–grafted PEEK-WC-PU membranes. Biomaterials 2009; 30 4348–4356
  22. De Bartolo, S. Salerno, E. Curcio, A. Piscioneri, M. Rende, S. Morelli, F. Tasselli, A. Bader, E. Drioli. Human hepatocyte functions in a crossed hollow fiber membrane bioreactor. Biomaterials 2009; 30:2531-2543.
  23. De Bartolo, M. Rende, S. Morelli, G. Giusi, S. Salerno, A. Piscioneri, A. Gordano, A. Di Vito, M. Canonaco, E. Drioli. Influence of membrane surface properties on the growth of neuronal cells isolated form hippocampus. J. Mem. Sci. 2008; 325: 139-149
  24. De Bartolo, S. Morelli, M. Rende, C. Campana, S. Salerno, N. Quintiero, E. Drioli, Human hepatocyte morphology and functions in a multibore fiber bioreactor. Macromolecular Bioscience 2007, 7:671-680.
  25. Memoli, L. De Bartolo, P. Favia, S. Morelli, L.C. Lopez, A. Procino, G. Barbieri, E. Curcio, L. Giorno, P. Esposito,, M. Cozzolino, D. Brancaccio, V.E. Andreucci, R. d’Agostino, E. Drioli Fetuin-A gene expression, synthesis and release in primary human hepatocytes cultured in a galactosylated membrane bioreactor. Biomaterials 2007; 28:4836-4844.
  26. Morelli, S. Salerno, M. Rende, L.C. Lopez, P. Favia, A. Procino, B. Memoli, V.E. Andreucci, R. d’Agostino, E. Drioli and L. De Bartolo. Human hepatocyte functions in galactosylated membrane bioreactor. J. Membrane Science 2007; 302:27-35.
  27. Curcio, S. Salerno, G. Barbieri, L. De Bartolo, E. Drioli A. Bader. Mass transfer and metabolic reactions in hepatocyte spheroids cultured in rotating wall gas-permeable membrane system. Biomaterials 2007; 28: 5487–5497.

 

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